Antibodies, also known as immunoglobulins, are specialized proteins produced by the immune system to identify and neutralize foreign invaders, such as viruses, bacteria, and other pathogens. They are ...
An antibody (teal) bound to its target, the HIV protein Env (white and gray), also attaches to an immune cell via a receptor (red) on the immune cell’s surface. This interaction can activate the ...
From this core mechanism Fc engineering has evolved over time into the "engine" of therapeutic antibody development. It enables precise modulation of immune effector functions, optimization of ...
A new approach targets the B-cell pathway with bispecific antibodies, building on decades of research that establishes the ...
"Solid tumors are often difficult to treat because the immune system within the tumor gets switched off," said Michelle H. Nelson, PhD, Director of Immunobiology at Aptevo. "APVO451 is designed to ...
A promising breakthrough in autoimmune disease research may open the door to safer and more effective treatments. Scientists ...
Aptevo Therapeutics (APVO) announced the first presentation of preclinical data for its new trispecific antibody, APVO451, at the Society for ...
An experimental treatment rejuvenates the immune system of older mice, improving the animals’ ability to fight infections. If it works in humans, the therapy could reverse age-related declines in ...