Just a few millimeters thick, articular cartilage plays a crucial role in our musculoskeletal system, since it is responsible for smooth (in the truest sense of the word) movement. However, the ...

Cartilage Oligomeric Matrix Protein (COMP) is a pentameric extracellular matrix glycoprotein that orchestrates collagen fibrillogenesis and maintains cartilage resilience. In healthy growth plates, ...

Current intra-articular drug delivery methods do not guarantee sufficient drug penetration into cartilage tissue to reach cell and matrix targets at the concentrations necessary to elicit the desired ...

Recently, a research team from Chongqing Medical University, led by Prof. Wei Huang, Dr. Wei Bao, and Dr. Yiting Lei, has successfully developed a novel engineered extracellular matrix (eECM) to ...

Stanford researchers have shown that blocking a single enzyme called 15-PGDH can regrow lost cartilage in aging mouse knees ...

In patients with severe osteoarthritis, cartilage can wear so thin that joints essentially transform into bone on bone — without a cushion between. A new therapy that uses synthetic nanofibers to ...

In November 2021, Northwestern University researchers introduced an injectable new therapy, which harnessed fast-moving "dancing molecules," to repair tissues and reverse paralysis after severe spinal ...

Cartilage injuries are a common clinical issue, often caused by trauma, severe infections, or degenerative joint diseases. The lack of direct blood supply to cartilage and limited access to nutrients ...

A new treatment that blocks an aging-related protein restored lost cartilage in old mice and helped prevent arthritis after ...

Expedition 74 crew members aboard the International Space Station are 3D-printing viable human cartilage tissues inside the ...

A working group develops strategies for regeneration of articular cartilage and has found that natural cartilage matrix is suitable as a biomaterial for improved cartilage regeneration. Just a few ...

Cartilage cells generate more protein components (collagen II and aggrecan) for regeneration when treated with fast-moving dancing molecules (left) compared to slower moving molecules. In November ...