K. pneumoniae is frequently the source of hospital-acquired infections and, due to the widespread use of antibiotics in these settings, has also acquired numerous resistance genes. In fact, over ...

Abdominal aortic aneurysms (AAA) often contain an intraluminal thrombus (ILT) which may contribute to aneurysm growth and rupture, but the mechanisms are not well understood. We hypothesized that ...

In a recent study posted to the bioRxiv* pre-print server, researchers investigated the complement component 1q (C1q) binding and subsequent complement activation by neutralizing antibodies (nAbs) ...

Discovery and development of biopharmaceuticals such as monoclonal antibodies requires extensive functional assessment in suitable bioassays that address safety (e.g. immunogenicity), physicochemical ...

The story of Q32 Bio, a company that develops therapeutics for inflammatory and autoimmune diseases, started two decades ago. That's when V. Michael Holers, MD, a University of Colorado School of ...

Dysfunction of the complement system plays an important role in the pathogenesis of renal diseases. Complement inhibitors, such as C5 inhibitors, have shown efficacy in clinical trials, but may no be ...

Antibody-mediated rejection (ABMR) remains the leading immunological cause of kidney allograft loss, yet its humoral origins are incompletely understood.