Helicases are specialised enzymes that translocate along DNA to unwind duplex structures, a fundamental step in replication, recombination and repair. Members of the RecQ family, notably the BLM ...

DNA helicases are motor proteins that translocate along nucleic acids to separate complementary strands, a step essential for replication, repair and recombination. By unwinding duplex DNA and ...

RO7589831, a new drug from Roche, is first in a new class of drugs called Werner helicase inhibitors Drug works similarly to other DNA damage repair inhibitors, such as PARP inhibitors This class of ...

Scientists at the University of Leicester have captured the first detailed “molecular movie” showing DNA being unzipped at the atomic level – revealing how cells begin the crucial process of copying ...

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...