Proteins are subject to post-translational chemical modifications that result in functional diversity. Methylation is one such modification that is generally believed to occur on lysine and arginine ...

Chemical changes to histones, the proteins that help to pack and organize DNA inside cells, play a key role in determining what genes will be consistently activated over the course of an animal or ...

In eukaryotes, genomic DNA, which is a very long double helix containing all the genetic information, wraps around a globular protein called a histone and folds it many times before being contained ...

One of the main goals of proteomics is to unravel the many modifications important for biological activity. Post-translational modifications (PTMs) extend the range of protein function by attaching it ...

A research team of 37 scientists, led by the Technical University of Munich, has developed a method to interrogate drug-induced post-translational modifications (PTMs) in a time and dose-dependent way ...

Post-translational modification is the last step in protein functional realization. Post-translational modification is a key mechanism to increase proteome diversity. Post-translational modification ...

Post-translational modifications (PTMs) play a key role in dynamic cellular processes, regulating gene expression, protein activity, localization, and degradation, as well as protein interaction.

The focus of vertebrate studies has mainly been on canonical phosphorylation, but research indicates that phosphorylation of other non-canonical amino acids also regulates integral aspects of cell ...

The amino acid side chains of proteins undergo various post-translational modifications (PTMs) which significantly impact protein function and mediate complex cellular events. Measuring the dynamics, ...

Ischemic stroke (IS) occurs when the blood and oxygen supply to a brain region is interrupted, leading to tissue necrosis 1. IS accounts for ~ 83% of all strokes, with the remainder being hemorrhagic ...

A new algorithm could drive breakthroughs in understanding cancer, Alzheimer's disease and other potentially fatal conditions ...

Tuberculosis is still one of the deadliest infectious diseases, causing over one million deaths each year worldwide. Additionally, about one-fourth of the world's population carries Mycobacterium ...